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Alzheimer’s Studies and Trials

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Apex study
Actively Enrolling
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APEX Study

The Alzheimer’s Plasma Extension (APEX) Study is a multicenter, observational study on Alzheimer’s disease (AD) related brain changes being conducted by Brigham and Women’s Hospital and University of Southern California (USC). An observational study is where researchers look at (or observe) changes over time without any study treatments. In this study, researchers will look at changes in blood tests, memory, and other factors that may predict who will accumulate brain amyloid over time, as well as factors that may help preserve memory and thinking in older individuals who do not develop elevated amyloid levels. The APEX Study consists of one in-person visit every year for four years in which blood samples, memory tests and questionnaires will be collected. Participation in this study will help researchers identify changes in blood tests, memory, and brain health that may occur years before people develop elevated brain amyloid and cognitive impairment and inform future clinical trials for Alzheimer’s disease.
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Trial-Ready Cohort- Down Syndrome (TRC-DS)

The Trial-Ready Cohort- Down Syndrome (TRC-DS) aims to enroll 450 non-demented adults (ages 25-55) with Down syndrome (DS) into a trial ready cohort (TRC). Participants enrolled in the TRC-DS will undergo longitudinal cognitive and clinical assessment, genetic and biomarker testing, as well as imaging and biospecimen collection. Using these outcome measures, researchers will analyze the relationships between cognitive measures and biomarkers of Alzheimer’s disease (AD) to identify endpoints for AD clinical trials in DS that best reflect disease progression.
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Longitudinal Early-Onset Alzheimer’s Disease Study (LEADS)

The LEADS study – or the Longitudinal Early-Onset Alzheimer’s Disease Study (LEADS) explores the development of early-onset Alzheimer’s disease and how it compares to the more common late-onset Alzheimer’s disease. Better understanding of this form of the disease may ultimately lead to more effective treatments. LEADS is a 2-year observational study designed to enroll 500 participants. Researchers are also recruiting cognitively normal volunteers for a 1-year comparison.
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Alzheimer Prevention Trials (APT) Webstudy

If you are 50 years of age or older, you can monitor your own cognitive health by participating in the Alzheimer Prevention Trials (APT) Webstudy. The APT Webstudy is designed to identify people who may have an increased risk for developing Alzheimer’s disease, using the latest technology to monitor their cognitive performance through regular online memory testing. Volunteers of the APT Webstudy participate at their convenience, anywhere they have access to the internet. If you are interested in the AlzMatch Study, it is currently on a hiatus.  If you would like to be considered for the AlzMatch Study in the future, please begin participation in the APT Webstudy.  Future invitations to AlzMatch will go out to eligible APT Webstudy participants.
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Actively Enrolling
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Alzheimer’s Disease Neuroimaging Initiative (ADNI)

The Alzheimer’s Disease Neuroimaging Initiative (ADNI), a landmark study that began in 2004, is a public-private research partnership tasked with identifying biomarkers to detect Alzheimer’s disease (AD). The study has gathered and analyzed thousands of brain scans, genetic profiles and biomarkers in blood and cerebrospinal fluid (CSF) and was designed to enable researchers to follow AD as it progresses in an individual, from various points in the disease process. The newest iteration of the study, called ADNI4, aims to recruit 750 new participants age 55-90 and bring over 750 rollover participants from ADNI3.
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Screening Closed
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AHEAD Study

AHEAD Study is a global multicenter clinical trial aimed at preventing memory loss due to Alzheimer’s disease, designed and conducted by the Alzheimer’s Clinical Trials Consortium (ACTC) in collaboration with Eisai. Funding is through a public-private partnership with National Institute on Aging (NIH), Eisai, and several philanthropic organizations. It is led by three academic principal investigators: Dr. Paul Aisen from University of Southern California, and Drs. Reisa Sperling and Keith Johnson from Brigham and Women’s Hospital and Massachusetts General Hospital, Harvard Medical School.
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Completed
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The LEARN Study

The LEARN study was funded by the Alzheimer’s Association to support the Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) study. The LEARN study is a companion study to the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4) study, a pioneering Alzheimer’s secondary prevention trial.
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Completed
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A4 Study

The landmark Anti-Amyloid Treatment in Asymptomatic Alzheimer’s study (A4 Study) enrolled 1,169 healthy older adults with normal memory but who might be at risk for Alzheimer’s due to family history of the disease and elevated levels of amyloid plaque in the brain. The primary study aims are to prevent the memory loss associated with the disease.
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Completed
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DOD ADNI

The purpose of DOD ADNI is to examine the possible connections between Traumatic Brain Injury (TBI) and Posttraumatic Stress Disorder (PTSD), and the signs and symptoms of AD on Veterans as they age. Approximately 300 Vietnam War Veterans, ages 50-90 will be eligible to participate in this study
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Closed
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EARLY Trial

The EARLY Trial was looking to determine the Efficacy and safety of atabecestat in participants who are Asymptomatic at Risk for developing Alzheimer’s dementia. The study sponsor, Janssen, sought to use the latest advances to assess a participant’s risk associated with beta-amyloid and memory loss, and test whether a treatment that reduces amyloid formation would slow memory loss associated with Alzheimer’s disease (AD).
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Completed
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Trial Ready Cohort for the Prevention of Alzheimer’s Dementia (TRC-PAD)

Those identified to have a potential increased risk for memory loss caused by Alzheimer’s disease were referred from the APT Webstudy (above) to the Trial Ready Cohort for the Prevention of Alzheimer’s Dementia (TRC-PAD) in-person study. The purpose of TRC-PAD was to find as many people as possible (also called a “cohort”) who were interested in participating in clinical trials aimed at discovering treatments to reduce the risk of developing Alzheimer’s dementia. TRC-PAD sought to help researchers enroll participants into these trials quickly to allow new treatments to be discovered as soon as possible.
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