The Alzheimer’s Disease Neuroimaging Initiative – Depression Project

What to expect from ADNI-D

Through a collaboration of scientists and researchers alike, ADNI-D’s efforts will expand the current state of research and help to bridge the gap between neurological research and mental health. The ADNI- D study shows great promise in developing a greater understanding of both mental illness and late life depression in relation to the cognitive decline in older adults. The information obtained from ADNI-D will also help streamline diagnostic processes and help the development of clinical treatment trials focuses specifically on late life depression and cognitive impairment. Additionally, the collaboration between UC San Francisco and ADNI is striving to improve health outcomes and reduce healthcare costs on a global scale. Through dynamic partnerships with the Alzheimer’s Disease Neuroimaging Initiative, psychiatric research programs, the Brain Health Registry, and industry sponsors, the ADNI-D program is confident in its ability to successfully achieve these goals and further the development of mental health research.


Recruitment and Involvement

The ADNI-D study will take place at two clinical sites across the United States. For the West Coast operation, volunteers will be recruited at the Langley Porter Psychiatric Institute located at the UCSF Parnassus campus as well as the Memory and Aging Center located at the UCSF Mission Bay campus. For the East Coast, volunteers will be recruited at the University of Pittsburgh.

The ADNI-D study is looking to recruit 120 volunteers ages 65 and older who meet the criteria for Major Depression or Late Life Depression, and will be a part of the study for a period of 2.5 years. Each volunteer in the ADNI-D study will have the opportunity to receive a MRI and PET scan of their brain in addition to collecting blood samples examining biological depression markers. Along with MRI’s, which look at the structure of the brain, PET scans will allow scientists to go a step further and examine how the different parts of the brain are functioning. Cognitive testing will also be conducted throughout the study to be compared to the biological testing results of the subjects. Each participant will be financially compensated for participating and due to the sensitive nature of the research; the investigators of ADNI-D are mandated by the federal Health Insurance Portability and Accountability Act in order to keep all participant identifiers confidential. In addition to other confidentiality protocols, the biological samples will be completely disassociated with the participants and will be identified only by a sample ID number. If interested in participating with your corresponding ADNI-D site, please call the number listed below.

University of California San Francisco: (415) 476-7046

University of Pittsburgh Pennsylvania: (412) 586-9061


  • In good general health
  • Age 65+
  • Currently experiencing symptoms of depression
  • Fluent in English
  • Willing to undergo one MRI scan and one PET scan
  • Willing to allow the collection of blood for testing