Alzheimer’s Studies and Trials

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The Alzheimer’s Plasma Extension (APEX) Study is a multicenter, observational study on Alzheimer’s disease (AD) related brain changes being conducted by Brigham and Women’s Hospital and University of Southern California (USC). An observational study is where researchers look at (or observe) changes over time without any study treatments. In this study, researchers will look at changes in blood tests, memory, and other factors that may predict who will accumulate brain amyloid over time, as well as factors that may help preserve memory and thinking in older individuals who do not develop elevated amyloid levels. The APEX Study consists of one in-person visit every year for four years in which blood samples, memory tests and questionnaires will be collected. Participation in this study will help researchers identify changes in blood tests, memory, and brain health that may occur years before people develop elevated brain amyloid and cognitive impairment and inform future clinical trials for Alzheimer’s disease.