DOD ADNI
A Study of Brain Aging in Vietnam War Veterans
“This Department of Defense funded project is the only one of its kind, aimed at determining if Traumatic Brain Injury (TBI) and/or Posttraumatic Stress Disorder (PTSD) cause Alzheimer’s disease. Vietnam Veterans with a history of TBI or PTSD are encouraged to join. I served in the U.S. Air Force during the Vietnam War, and I have personally undergone all the tests of this study myself.”
Michael Weiner, M.D.
Professor, ADNI Principal Investigator
Director, Center for Imaging of Neurodegenerative Disease
San Francisco VA Medical Center
Overview
On behalf of Yale University and the Alzheimer’s Therapeutic Research Institute (ATRI), we want to thank everyone for their participation in the FYN (Connect) study to evaluate the drug AZD0530 treatment was found to be safe and well-tolerated by most individuals at the doses tested (100 or 125mg daily).
However, treatment with AZD0530, did not demonstrate any benefit for the primary aim of the study, which was to preserve brain function as measured by the PET scans. It also did not show an advantage in the assessments of memory and daily functioning. Additional analyses are in progress, and the results will be reported to all clinical site, principal investigators.